Protein Crystallography

High-precision, high-accuracy macromolecular crystallography

I introduce a novel concept of high-energy data acquisition with a highly optimized setup and workflow for protein crystallography. I will present how the implementation of these procedures allows us to routinely collect single-crystal datasets at atomic and sub-Å resolution.

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The Segregated Atom Model for the refinement of high-resolution diffraction experiments

We aim to include chemical bonding effects within the refinement techniques from structural biology by integrating covalent bond analysis methodologies with contemporary structure refinement techniques.

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