Abstracts

Electron Diffraction and Quantum Crystallography

Focusing on both complex protein structures and small organic molecules, the lecture will explain how adapting electron density models from X‑ray diffraction to electron-based techniques can transform our understanding of molecular interactions and structures on the nanoscale

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Charge Density Analysis of Organic Nanocrystals via 3D ED Data

I will give a short introduction into techniques for chemical-bonding analysis from single-crystal diffraction data (multipole modeling, X-ray wavefunction refinement) and into quantum-chemical methods for deriving bonding descriptors

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Electron Diffraction for Charge Density Studies: Historical Perspectives and Modern Data Processing Considerations

Charge density research and electron diffraction share well-established historical connection. This presentation provides a concise overview of various electron diffraction and microscopy techniques capable of yielding valuable charge density information

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Quantum crystallography and NMR crystallography

A weakness of current NMR crystallography for organic solids is the relatively poor positioning of H by independent atom modelling in XRD refinement. In order to obtain reasonable agreement with NMR data

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Data Quality

Crystallography has established a de-facto, well-understood, level of quality in its data over many decades. This is largely based on a long history of standardised instrumentation

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AI can provide phases at 2 Å: Can Quantum Crystallography help us to a high-quality structure at this resolution?

By exploring the intersection of AI and quantum crystallography, we aim to spark a dialogue on how these fields can co-evolve to tackle the enduring challenges of structural determination in the low-resolution regime.

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Defining Tools for Complex Small Molecules to Enable Assessment of Quality and Appropriate Reuse of Data

An important, but often difficult to evaluate, aspect of small molecule crystallographic structure analysis is an understanding of how a refinement has been performed. One of the tools tha can be used is to evaluate the likelihood of a given bond in a structure, and from this calculate the total likelihood of the structure

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QCrBox: A Containerised Platform for Quantum Crystallographic Workflows

We will report on our progress to build a similarly user-friendly platform, that focusses on reducing practical barriers such as complex multi-software workflows, interoperability challenges, and installation difficulties across diverse operating systems and software dependencies.

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The QCr CIF Dictionary

An update on the QCr CIF dictionary, which is currently under development.

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